Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.

ABSTRACT: Rationale: Birth cohort studies have identified several temporal patterns of wheezing, only some of which are associated with asthma. Whether 17q12-21 genetic variants, which are closely associated with asthma, are also associated with childhood wheezing phenotypes remains poorly explored.Objectives: To determine whether wheezing phenotypes, defined by latent class analysis (LCA), are associated with nine 17q12-21 SNPs and if so, whether these relationships differ by race/ancestry.Methods: Data from seven U.S. birth cohorts (n = 3,786) from the CREW (Children's Respiratory Research and Environment Workgroup) were harmonized to represent whether subjects wheezed in each year of life from birth until age 11 years. LCA was then performed to identify wheeze phenotyp

SUBMITTER: Hallmark B 

PROVIDER: S-EPMC8017591 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature