H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum.

ABSTRACT:

Background

The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological changes from commitment to maturity, directed by an equally extensive control program. However, the processes that drive the differentiation and development of the gametocyte post-commitment, remain largely unexplored. A previous study reported enrichment of H3K36 di- and tri-methylated (H3K36me2&3) histones in early-stage gametocytes. Using chromatin immunoprecipitation followed by high-throughput sequencing, we identify a stage-specific association between these repressive histone modifications and transcriptional reprogramming that define a stag

SUBMITTER: Connacher J 

PROVIDER: S-EPMC8017609 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature