The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics.

ABSTRACT: The circadian system temporally regulates physiology to maintain homeostasis. Co-opting and disrupting circadian signals appear to be distinct attributes that are functionally important for the development of a tumor and can enable or give rise to the hallmarks that tumors use to facilitate their initiation, growth and progression. Because circadian signals are also strong regulators of immune cell proliferation, trafficking and exhaustion states, they play a role in how tumors respond to immune-based cancer therapeutics. While immuno-oncology has heralded a paradigm shift in cancer therapeutics, greater accuracy is needed to increase our capability of predicting who will respond favorably to, or who is likely to experience the troubling adverse effects of, immunotherapy. Insights into cir

SUBMITTER: Cash E 

PROVIDER: S-EPMC8017624 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature