Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.

ABSTRACT: Exacerbated immune responses and loss of self-tolerance lead to the development of autoimmunity and immunopathology. Novel therapies to target autoreactive T cells are still needed. Here, we report that Th2-polarized T cells lacking the transcription factor T-bet harbor strong immunomodulatory potential and suppress antigen-specific CD8⁺ T cells via IL-10. Tbx21^-/- Th2 cells protected mice against virus-induced type 1 diabetes development and suppressed not only naive but also memory CD8⁺ T cell responses. IL-10-producing, but not IL-10-deficient Tbx21^-/- Th2 cells down-regulated costimulatory molecules on dendritic cells and reduced their IL-12 production after lymphocytic choriomeningitis virus infection. Impaired dendritic cell a

SUBMITTER: Munoz M 

PROVIDER: S-EPMC8017670 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature