Association between insulin resistance and lung function trajectory over 4 years in South Korea: community-based prospective cohort.

ABSTRACT:

Background

Hyperglycemic conditions are associated with respiratory dysfunction. Although several studies have reported that insulin resistance (IR) is related to decreased lung function, the association between IR and change in lung function has been rarely studied. This study aimed to investigate the potential association of IR on annual change in lung function using a community-based prospective cohort in Korea.

Methods

We selected 4827 Korean participants whose serial lung functions were assessed over 4 years using 1:3 propensity score matching. Exposure was baseline IR estimated with homeostatic model assessment (HOMA-IR), and outcomes were annual changes in lung function determined by calculating the regression coefficient using least-square linear regression analysis.

SUBMITTER: Kim SH 

PROVIDER: S-EPMC8017677 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature