Microfluidic guillotine reveals multiple timescales and mechanical modes of wound response in Stentor coeruleus.

ABSTRACT:

Background

Wound healing is one of the defining features of life and is seen not only in tissues but also within individual cells. Understanding wound response at the single-cell level is critical for determining fundamental cellular functions needed for cell repair and survival. This understanding could also enable the engineering of single-cell wound repair strategies in emerging synthetic cell research. One approach is to examine and adapt self-repair mechanisms from a living system that already demonstrates robust capacity to heal from large wounds. Towards this end, Stentor coeruleus, a single-celled free-living ciliate protozoan, is a unique model because of its robust wound healing capacity. This capacity allows one to perturb the wounding conditions and measure their effect

SUBMITTER: Zhang KS 

PROVIDER: S-EPMC8017755 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature