Combined effects of composting and antibiotic administration on cattle manure-borne antibiotic resistance genes.

ABSTRACT:

Background

Research is needed to delineate the relative and combined effects of different antibiotic administration and manure management practices in either amplifying or attenuating the potential for antibiotic resistance to spread. Here, we carried out a comprehensive parallel examination of the effects of small-scale (> 55 °C × 3 days) static and turned composting of manures from dairy and beef cattle collected during standard antibiotic administration (cephapirin/pirlimycin or sulfamethazine/chlortetracycline/tylosin, respectively), versus from untreated cattle, on "resistomes" (total antibiotic resistance genes (ARGs) determined via shotgun metagenomic sequencing), bacterial microbiota, and indicator ARGs enumerated via quantitative polymerase chain reaction. To gain insight

SUBMITTER: Keenum I 

PROVIDER: S-EPMC8017830 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature