Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases.

ABSTRACT:

Background

Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). This technique is, however, limited by its applicability in space and time. Phase-contrast MRI has yet to be compared directly with CSF tracer enhanced imaging, which can be considered gold standard for assessing long-term CSF flow dynamics within the intracranial compartment.

Methods

Here, we studied patients with various CSF disorders and compared MRI biomarkers of CSF space anatomy and phase-contrast MRI at level of the aqueduct and cranio-cervical junction with dynamic intrathecal contrast-enhanced MRI using the contrast agent gadobutrol as CSF tracer. Tra

SUBMITTER: Eide PK 

PROVIDER: S-EPMC8017867 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature