Immunological significance of prognostic alternative splicing signature in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which might act an important factor in tumorigenesis. This study aimed to construct of AS-based prognostic signature and elucidate the role in tumor immune microenvironment (TIME) and immunotherapy in HCC.

Methods

Univariate Cox regression analysis was performed to determine the prognosis-related AS events and gene set enrichment analysis (GSEA) was employed for functional annotation, followed by the development of prognostic signatures using univariate Cox, LASSO and multivariate Cox regression. K-M survival analysis, proportional hazards model, and ROC curves were conducted to validate prognostic value

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8017877 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature