New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies.

ABSTRACT:

Background

Numerous studies have reported the correlation between AXIN2 polymorphism and cancer risk, but the results seem not consistent. In order to get an overall, accurate and updated results about AXIN2 polymorphism and cancer risk, we conducted this study.

Methods

An updated analysis was performed to analyze the correlation between AXIN2 polymorphisms and cancer risk. Linkage disequilibrium (LD) analysis was also used to show the associations.

Results

Seventy-two case-control studies were involved in the study, including 22,087 cases and 18,846 controls. The overall results showed rs11079571 had significant association with cancer risk (allele contrast model: OR = 0.539, 95%CI = 0.478-0.609, PAdjust = 0.025; homozygote model: OR = 0.22, 95% CI = 0.164-0.295, PAd

SUBMITTER: Li X 

PROVIDER: S-EPMC8017882 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature