Intercellular communication induces glycolytic synchronization waves between individually oscillating cells.

ABSTRACT: Many organs have internal structures with spatially differentiated and sometimes temporally synchronized groups of cells. The mechanisms leading to such differentiation and coordination are not well understood. Here we design a diffusion-limited microfluidic system to mimic a multicellular organ structure with peripheral blood flow and test whether a group of individually oscillating yeast cells could form subpopulations of spatially differentiated and temporally synchronized cells. Upon substrate addition, the dynamic response at single-cell level shows glycolytic oscillations, leading to wave fronts traveling through the monolayered population and to synchronized communities at well-defined positions in the cell chamber. A detailed mechanistic model with the architectural structure of th

SUBMITTER: Mojica-Benavides M 

PROVIDER: S-EPMC8017953 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature