Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.

ABSTRACT: Triggering receptor expressed on myeloid cells 2 TREM2 was identified as a risk factor for late onset Alzheimer's disease (AD). Here we compared TREM2 cases with a variant (TREM2⁺ ) and cases without a TREM2 variant (TREM2^- ), considering pathological burden, inflammatory response and altered canonical pathways and biochemical functions between the cohorts. We hypothesised that TREM2⁺ cases would have a loss of function, indicating an altered inflammatory profile compared to TREM2^- cases. Immunohistochemistry was performed using antibodies against Aβ, tau and microglia markers in TREM2⁺ cases, with and without AD, which were compared to sporadic TREM2^- AD, familial AD and neurologically normal control cases. Aβ and tau load

SUBMITTER: Toomey CE 

PROVIDER: S-EPMC8018003 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature