MicroRNA profiles of MS gray matter lesions identify modulators of the synaptic protein synaptotagmin-7.
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ABSTRACT:
SUBMITTER: Fritsche L
PROVIDER: S-EPMC8018161 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
MicroRNA profiles of MS gray matter lesions identify modulators of the synaptic protein synaptotagmin-7.
Fritsche Lena L Teuber-Hanselmann Sarah S Soub Daniel D Harnisch Kim K Mairinger Fabian F Junker Andreas A
Brain pathology (Zurich, Switzerland) 20191117 3
We established microRNA (miRNA) profiles in gray and white matter multiple sclerosis (MS) lesions and identified seven miRNAs which were significantly more upregulated in the gray matter lesions. Five of those seven miRNAs, miR-330-3p, miR-4286, miR-4488, let-7e-5p, miR-432-5p shared the common target synaptotagmin7 (Syt7). Immunohistochemistry and transcript analyses using nanostring technology revealed a maldistribution of Syt7, with Syt7 accumulation in neuronal soma and decreased expression ...[more]
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