Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance.

ABSTRACT:

Objective

The intestinal flora of gut microbiota in obese Chinese children and adolescents with and without insulin resistance (IR) was analyzed, as well as associations between the gut microbiota and two serum cytokines related to glucose metabolism, adropin and angiopoietin-like 4 (ANGPTL4).

Methods

Clinical data, fecal bacterial composition, glucose-related hormones, and serum adipokines (adropin and ANGPTL4) were analyzed in 65 Chinese children with exogenous obesity. The composition of the gut microbiota was determined by 16S rRNA-based metagenomics and IR was calculated using the homeostasis model assessment (HOMA).

Results

The 65 obese subjects were divided into two groups: insulin sensitive (IS) (n=40, 57.5% males) or IR (n=25, 60% males). Principal coordinate

SUBMITTER: Yuan X 

PROVIDER: S-EPMC8018175 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature