The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-θ signaling.

ABSTRACT: Ischemic stroke is a common cerebrovascular disease with the main cause considered to be cerebral ischemia and reperfusion (I/R), which exerts irreparable injury on nerve cells. Thus, the development of neuroprotective drugs is an urgent concern. Curcumin, a known antioxidant, has been found to have neuroprotective effects. To determine the protective mechanism of curcumin in ischemic stroke, oxygen and glucose deprivation/reoxygenation (OGD/R) was used to treat PC12 cells to mimic the cerebral I/R cell model. Curcumin (20 μM) was applied to OGD/R PC12 cells, followed by Ca²⁺ concentration, transepithelial electrical resistance (TEER), and cell permeability measurements. The results showed that OGD/R injury induced a decrease in TEER and increases in Ca²⁺ concentratio

SUBMITTER: Mo Y 

PROVIDER: S-EPMC8018382 | biostudies-literature | 2021 Mar-Mar

REPOSITORIES: biostudies-literature