Aconiti lateralis Radix Praeparata inhibits Alzheimer's disease by regulating the complex regulation network with the core of GRIN1 and MAPK1.

ABSTRACT:

Context

Current medicine for Alzheimer's disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal.

Objective

Analysing the anti-AD effect of Fuzi and its potential molecular mechanism.

Materials and methods

AD model cells were treated with Fuzi in 0-300 mg/mL for 24 h in 37 °C. The cell viability (CV) and length of cell projections (LCP) for each group were observed, analysed, and standardised using control as a baseline (CV_s and LCP_s). The Fuzi and AD relevant genes were identified basing on databases, and the molecular mechanism of Fuzi anti-AD was predicted by network analysis.

Results

Experiment results sho

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8018400 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature