P53 regulates cellular redox state, ferroptosis and metabolism.
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ABSTRACT:
SUBMITTER: Leu JI
PROVIDER: S-EPMC8018455 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
P53 regulates cellular redox state, ferroptosis and metabolism.
Leu Julia I-Ju JI Murphy Maureen E ME George Donna L DL
Molecular & cellular oncology 20210208 2
The tumor protein <i>P53</i> (<i>TP53</i>, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis. ...[more]
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