Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.

ABSTRACT:

Aims

Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resistance and NAFLD have not been thoroughly investigated. Moreover, it has recently been suggested that TMAO could play a role in NAFLD by altering bile acid metabolism. We examined the association between circulating TMAO, choline and betaine levels and NAFLD in obese subjects.

Methods

Serum TMAO, choline, betaine and bile acid levels were measured in 357 Mexican obese patients with different grades of NAFLD as determined by liver histology. Associations of NAFLD w

SUBMITTER: Leon-Mimila P 

PROVIDER: S-EPMC8018562 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature