Impact of hepatitis C virus treatment on the risk of non-hepatic cancers among hepatitis C virus-infected patients in the US.

ABSTRACT:

Background

Hepatitis C virus (HCV) infection is associated with with an increased risk of non-hepatic cancers, but the impact of HCV treatment on non-hepatic cancer is unclear.

Aims

To assess if HCV treatment reduced the incidence of non-hepatic cancers among patients with chronic HCV infection in the US.

Methods

We conducted a retrospective cohort study in MarketScan Databases from January 2005 to December 2016. Multivariable, time-varying Cox proportional-hazards models were used to determine hazard ratios (HRs) of incident non-hepatic cancers in treated and untreated patients with HCV infection. We conduscted subgroup analyses for sex, age, and presence of cirrhosis or diabetes.

Results

Among 62 078 patients with newly diagnosed HCV infection, 17 302 (28%) i

SUBMITTER: Wang W 

PROVIDER: S-EPMC8018581 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature