Double drives and private alleles for localised population genetic control.

ABSTRACT: Synthetic gene drive constructs could, in principle, provide the basis for highly efficient interventions to control disease vectors and other pest species. This efficiency derives in part from leveraging natural processes of dispersal and gene flow to spread the construct and its impacts from one population to another. However, sometimes (for example, with invasive species) only specific populations are in need of control, and impacts on non-target populations would be undesirable. Many gene drive designs use nucleases that recognise and cleave specific genomic sequences, and one way to restrict their spread would be to exploit sequence differences between target and non-target populations. In this paper we propose and model a series of low threshold double drive designs for population su

SUBMITTER: Willis K 

PROVIDER: S-EPMC8018619 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature