Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease.

ABSTRACT:

Aim

Osteoporotic fractures negatively impact health-related quality of life and prognosis. Advanced glycation end products (AGEs) impair bone quality and reduce bone strength. The aim of this study was to determine the relationship between plasma levels of pentosidine, a surrogate marker for AGEs, and prevalent fractures in patients with chronic liver disease (CLD).

Methods

This cross-sectional study included 324 patients with CLD. Vertebral fractures were evaluated using lateral thoracolumbar spine radiographs. Information on prevalent fractures was obtained through a medical interview, medical records, and/or radiography. The patients were classified into low (L), intermediate (I), and high (H) pentosidine (Pen) groups based on baseline plasma pentosidine levels.

Result

SUBMITTER: Saeki C 

PROVIDER: S-EPMC8018620 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature