NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D₂ Receptor Stimulation: Involvement in Behavioral Repetition.

ABSTRACT: Repetitive behavior is a widely observed neuropsychiatric symptom. Abnormal dopaminergic signaling in the striatum is one of the factors associated with behavioral repetition; however, the molecular mechanisms underlying the induction of repetitive behavior remain unclear. Here, we demonstrated that the NOX1 isoform of the superoxide-producing enzyme NADPH oxidase regulated repetitive behavior in mice by facilitating excitatory synaptic inputs in the central striatum (CS). In male C57Bl/6J mice, repeated stimulation of D₂ receptors induced abnormal behavioral repetition and perseverative behavior. Nox1 deficiency or acute pharmacological inhibition of NOX1 significantly shortened repeated D₂ receptor stimulation-induced repetitive behavior without affecting mot

SUBMITTER: Asaoka N 

PROVIDER: S-EPMC8018731 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature