Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.

ABSTRACT:

Background

A number of studies have examined the association between mold exposure and childhood asthma. However, the conclusions were inconsistent, which might be partly attributable to the lack of consideration of gene function, especially the key genes affecting the pathogenesis of childhood asthma. Research on the interactions between genes and mold exposure on childhood asthma is still very limited. We therefore examined whether there is an interaction between inflammation-related genes and mold exposure on childhood asthma.

Methods

A case-control study with 645 asthmatic children and 910 non-asthmatic children aged 3-12 years old was conducted. Eight single nucleotide polymorphisms (SNPs) in inflammation-related genes were genotyped using MassARRAY assay. Mold exposure

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8019181 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature