Accuracy of penicillin allergy diagnostic tests: A systematic review and meta-analysis.

ABSTRACT:

Background

Having a penicillin allergy label associates with a higher risk for antibiotic resistance and increased health care use.

Objective

We sought to assess the accuracy of skin tests and specific IgE quantification in the diagnostic evaluation of patients reporting a penicillin/β-lactam allergy.

Methods

We performed a systematic review and diagnostic accuracy meta-analysis, searching on MEDLINE, Scopus, and Web of Science. We included studies conducted in patients reporting a penicillin allergy and in whom skin tests and/or specific IgE quantification were performed and compared with drug challenge results. We quantitatively assessed the accuracy of diagnostic tests with bivariate random-effects meta-analyses. Meta-regression and subgroup analyses were performed

SUBMITTER: Sousa-Pinto B 

PROVIDER: S-EPMC8019189 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature