Induction of diverse T cell memory through antibody-mediated activation in mice.

ABSTRACT: Recent studies have demonstrated that laboratory mice lack a robust repertoire of memory T cell. Administration of an anti-CD3ε activating antibody (clone 145-2C11) induces persistent CD4 and CD8 T cell memory in both lymphatic and solid organs while maintaining T cell responses and without increased anergy or altering innate immunity.

SUBMITTER: Taylor MD 

PROVIDER: S-EPMC8019190 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature