Characteristics of B lymphocyte infiltration in HPV⁺ head and neck squamous cell carcinoma.

ABSTRACT: Human papillomavirus (HPV) is an important etiological factor of head and neck squamous cell carcinoma (HNSCC). HPV⁺ HNSCC patients usually have a better prognosis, which probably results from the higher infiltration of B lymphocytes. This study was purposed to detect the infiltration of B lymphocyte subsets and the correlation between B lymphocyte subsets and the prognosis in HPV-related HNSCC. In this study, 124 HPV⁺ and 513 HPV^- HNSCC samples were obtained from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database for transcriptomic analysis. Infiltration of B lymphocytes subsets was detected with 7 HPV⁺ HNSCC and 13 HPV^- HNSCC tissues through immunohistochemistry and immunofluorescence. One HPV

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8019230 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature