Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG.

ABSTRACT: Tissue-resident memory T cells (T_RM) are different from effector memory T cells (T_EM) and central memory T cells (T_CM) and contribute to the protective immunity against local challenges. Currently, we found that CD4⁺ and CD8⁺ T_RM cells in the nasal mucosa, trachea, lungs, and lavage fluids were heterogeneous on the expression of CD69 and CD103 as well as the production of cytokines including IFN-γ, IL-2, and TNF-α. After intranasal vaccination of mice with BCG, respiratory tissues expressed higher levels of the chemokine CXCL16 and T_RM cells expressed CXCR6 to CXCL16. In addition, antigen-specific CD4⁺ and CD8⁺ T_RM cells expressed cytokines following the stimulation w

SUBMITTER: Wu Q 

PROVIDER: S-EPMC8019380 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature