A novel method to establish the rabbit model of knee osteoarthritis: intra-articular injection of SDF-1 induces OA.

ABSTRACT:

Background

Animal model of Knee Osteoarthritis (OA) is the primary testing methodology for studies on pathogenic mechanisms and therapies of human OA disease. Recent major modeling methods are divided into artificially induced and spontaneous. However, these methods have some disadvantages of slow progression, high cost and no correlation with the pathogenesis of OA.

Methods

Our studies attempted to find a rapid, easy, and consistent with the natural pathological process of OA modeling method by intra-articular injection of stromal cell-derived factor 1 (SDF-1) in the rabbit knee. After induction we collected cartilage specimens from the medial femoral condyle to undergo macroscopic, histological, immunohistochemical, and biochemical evaluations. Meanwhile, compared with Hul

SUBMITTER: Li C 

PROVIDER: S-EPMC8019508 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature