Liraglutide-induced structural modulation of the gut microbiota in patients with type 2 diabetes mellitus.

ABSTRACT: Accumulating evidence has suggested the importance of gut microbiota in the development of type 2 diabetes mellitus (T2DM). In the present study, 40 patients with T2DM were treated with liraglutide for 4 months. Feces samples and clinical characteristics were collected from these 40 T2DM patients before and after the liraglutide treatment. The diversity and composition of gut microbiota in the two groups were determined by sequencing the V4 region of bacterial 16S rRNA genes. Meanwhile, blood glucose, insulin, hemoglobin A1c (HbA1c), and lipid metabolism were also measured in the pre- and post-liraglutide-treatment groups. We find that Baseline HbA1c was associated with liraglutide treatment response (R ₂ = 0.527, β =  - 0.726, p < 0.0001). After adjusted fo

SUBMITTER: Shang J 

PROVIDER: S-EPMC8019531 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature