Ontology highlight
ABSTRACT:
SUBMITTER: Le D
PROVIDER: S-EPMC8019596 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Le Dai D Lim Soyeon S Min Kwang Wook KW Park Joon Woo JW Kim Youjoung Y Ha Taejeong T Moon Kyeong Hwan KH Wagner Kay-Uwe KU Kim Jin Woo JW
Molecules and cells 20210301 3
The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking. Thus, we deleted tumor <i>susceptibility gene</i> 101 (<i>Tsg101</i>), a key component of endosomal sorting co ...[more]