Transcriptomic Analysis of Cellular Senescence: One Step Closer to Senescence Atlas.

ABSTRACT: Senescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context of senescent cells, in vivo studies are needed to increase the understanding of senescent cells. Since current methods are often unable to distinguish senescent cells from other cells, efforts are being made to find markers commonly expressed in senescent cells using bulk RNA-sequencing. More

SUBMITTER: Kim S 

PROVIDER: S-EPMC8019598 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature