Association of Interleukin-1α Functional Polymorphism with Risk of Chronic Periodontitis in Han Chinese Population.

ABSTRACT: Chronic periodontitis (CP) is a common inflammatory illness affecting a large proportion of humans. Genetic factors are thought to play important roles in its onset and development. A functional polymorphism (rs1800587) in the promoter of the interleukin-1α gene (-889 C/T) has been found to confer risk of CP primarily in Europeans, but the association between this variant and CP in the Chinese population remains less conclusive. In the current study, we aimed to investigate the association between rs1800587 and CP in case-control samples of Han Chinese origin. A total of 1,777 study subjects, including 884 CP patients and 893 healthy controls, were collected. Genotyping of rs1800587 was performed using the SNAPSHOT method, and statistical analyses were conducted to evaluate the asso

SUBMITTER: She X 

PROVIDER: S-EPMC8019642 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature