Safety of Intravenous Heparin for Cardiac Surgery in Patients With Alpha-Gal Syndrome.

ABSTRACT:

Background

Alpha-gal syndrome is a tick-acquired disease caused by immunoglobulin E (IgE) to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), causing allergic reactions to meat and products sourced from nonprimate mammals. As heparin is porcine-derived, we hypothesized that patients with alpha-gal syndrome who received high-dose heparin for cardiac surgery would have increased risk of anaphylaxis.

Methods

All cardiac surgery patients at an academic medical center from 2007 to 2019 were cross-referenced with research and clinical databases for the alpha-gal IgE blood test. Clinical data were obtained through the institutional Society of Thoracic Surgeons Adult Cardiac Database and chart review. Patients were stratified by development of an allergic reaction for

SUBMITTER: Hawkins RB 

PROVIDER: S-EPMC8019687 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature