Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets.

ABSTRACT: Diverse populations of natural killer (NK) cells have been identified in circulating peripheral blood and a wide variety of different tissues and organs. These tissue-resident NK cell populations are phenotypically distinct from circulating NK cells, however, functional descriptions of their roles within tissues are lacking. Recent advances in single cell RNA sequencing (scRNA-seq) have enabled detailed transcriptional profiling of tissues at the level of single cells and provide the opportunity to explore NK cell diversity within tissues. This review explores potential novel functions of human liver-resident (lr)NK cells identified in human liver scRNA-seq studies. By comparing these datasets we identified up-regulated and down-regulated genes associated with lrNK cells clusters. These ge

SUBMITTER: Jameson G 

PROVIDER: S-EPMC8019706 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature