Autophagy Promotes Cigarette Smoke-Initiated and Elastin-Driven Bronchitis-Like Airway Inflammation in Mice.

ABSTRACT: Cigarette smoke (CS)-induced macrophage activation and airway epithelial injury are both critical for the development of chronic obstructive pulmonary disease (COPD), while the eventual functions of autophagy in these processes remain controversial. We have recently developed a novel COPD mouse model which is based on the autoimmune response sensitized by CS and facilitated by elastin. In the current study, we therefore utilized this model to investigate the roles of autophagy in different stages of the development of bronchitis-like airway inflammation. Autophagic markers were increased in airway epithelium and lung tissues, and Becn^+/- or Lc3b^-/- mice exhibited reduced neutrophilic airway inflammation and mucus hyperproduction in this COPD m

SUBMITTER: Huang HQ 

PROVIDER: S-EPMC8019710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature