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Frequency of Effector Memory Cells Expressing Integrin α₄β₇ Is Associated With TGF-β1 Levels in Therapy Naive HIV Infected Women With Low CD4⁺ T Cell Count.

ABSTRACT: Integrin α₄β₇ expressing CD4⁺ T cells are preferred targets for HIV infection and are thought to be predictors of disease progression. Concurrent analysis of integrin α₄β₇ expressing innate and adaptive immune cells was carried out in antiretroviral (ART) therapy naïve HIV infected women in order to determine its contribution to HIV induced immune dysfunction. Our results demonstrate a HIV infection associated decrease in the frequency of integrin α₄β₇ expressing endocervical T cells along with an increase in the frequency of integrin α₄β₇ expressing peripheral monocytes and central memory CD4⁺ T cells, which are considered to be viral reservoirs. We report for the first time an in

SUBMITTER: Kasarpalkar NJ

PROVIDER: S-EPMC8019712 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Frequency of Effector Memory Cells Expressing Integrin α₄β₇ Is Associated With TGF-β1 Levels in Therapy Naive HIV Infected Women With Low CD4⁺ T Cell Count.

OmicsDI is part of the ELIXIR infrastructure

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Frequency of Effector Memory Cells Expressing Integrin α4β7 Is Associated With TGF-β1 Levels in Therapy Naive HIV Infected Women With Low CD4+ T Cell Count.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Frequency of Effector Memory Cells Expressing Integrin α₄β₇ Is Associated With TGF-β1 Levels in Therapy Naive HIV Infected Women With Low CD4⁺ T Cell Count.