Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y₁₂ Receptor Activation.

ABSTRACT: Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden to patients, it challenges wound care professionals and causes a great financial cost to health system. Considering the absence of effective treatments for chronic wounds, our aim was to better understand the pathophysiology of tissue repair in diabetes in order to find alternative strategies to accelerate wound healing. Nucleotides have been described as extracellular signaling molecules in different inflammatory processes, including tissue repair. Adenosine-5'-diphosphate (ADP) plays important roles in vascular and cellular response and is immediately released after tissue injury, mainly from platelets. However, despite the well described effect on platelet aggrega

SUBMITTER: Borges PA 

PROVIDER: S-EPMC8019717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature