Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease.

ABSTRACT: Cardiovascular diseases are one of the leading causes of death and global health problems worldwide. Multiple factors are known to affect the cardiovascular system from lifestyles, genes, underlying comorbidities, and age. Requiring high workload, metabolism of the heart is largely dependent on continuous power supply via mitochondria through effective oxidative respiration. Mitochondria not only serve as cellular power plants, but are also involved in many critical cellular processes, including the generation of intracellular reactive oxygen species (ROS) and regulating cellular survival. To cope with environmental stress, mitochondrial function has been suggested to be essential during bioenergetics adaptation resulting in cardiac pathological remodeling. Thus, mitochondrial dysfunction

SUBMITTER: Lin KL 

PROVIDER: S-EPMC8019794 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature