LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer.

ABSTRACT:

Background and objective

Gastric cancer (GC) is a common tumor malignancy with high incidence and poor prognosis. Laminin is an indispensable component of basement membrane and extracellular matrix, which is responsible for bridging the internal and external environment of cells and transmitting signals. This study mainly explored the association of the LAMB1 expression with clinicopathological characteristics and prognosis in gastric cancer.

Methods

The expression data and clinical information of gastric cancer patients were downloaded from The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG). And we analyzed the relationship between LAMB1 expression and clinical characteristics through R. CIBERSORTx was used to calculate the absolute score of immune cells

SUBMITTER: Ran T 

PROVIDER: S-EPMC8020091 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature