Update on systemic treatment for newly diagnosed inflammatory breast cancer.

ABSTRACT:

Background

Inflammatory breast cancer (IBC) is a rare and aggressive disease, accounting for 2-4% of new cases of breast cancer. Owing to its aggressive nature, IBC represent approximately 8-10% of breast cancer deaths. Management of IBC requires a multidisciplinary team for decision-making involving a composite of systemic treatment, surgery, and radiation, or "Trimodality Treatment." Because of the rarity of the disease, systemic therapy of IBC traditionally has been extrapolated from non-IBC clinical trials.

Aim of review

The purpose of this review is to provide an overview of the development of systemic treatment of IBC from the past to the present by focusing on IBC clinical trials, including chemotherapy and targeted therapies.

Key scientific concepts of review

SUBMITTER: Chainitikun S 

PROVIDER: S-EPMC8020152 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature