Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC8020258 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Li Ruyi R Song Peng P Tang Guofang G Wei Jianghong J Rao Lizong L Ma Libing L Jiang Ming M Huang Jianwei J Xu Qing Q Wu Jingjie J Lv Qian Q Yao Dong D Xiao Bo B Huang Haiming H Lei Liping L Feng Juntao J Mo Biwen B
Frontiers in pharmacology 20210322
Inhibition of activated macrophages is an alternative therapeutic strategy for asthma. We investigated whether a coumarin compound, osthole, isolated from <i>Cnidium</i> <i>monnieri</i> (L.) Cuss, alleviated macrophage activation <i>in vivo</i> and <i>in vitro</i>. Osthole could reduce expression of a marker of activated macrophages, cluster of differentiation (CD)206, in an ovalbumin-challenge model of asthma in mice. Osthole could also inhibit infiltration of inflammatory cells, collagen depos ...[more]