Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota.

ABSTRACT:

Background

Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in vivo.

Methods

Sprague Dawley rats were administered with ginsenoside Rb1 after a two-week prebiotic intervention of fructooligosaccharide, galactooligosaccharide, and fibersol-2, respectively. Pharmacokinetic analysis of ginsenoside Rb1 and its metabolites was performed, whilst the microbial composition and metabolic function of gut microbiota were examined by 16S rRNA gene amplicon and metagenomic shotgun sequencing.

Results

The results showed that peak plasma concentration and area under concentration time curve of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8020290 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature