Metabolic osteoarthritis - relation of diabetes and cardiovascular disease with knee osteoarthritis.

ABSTRACT:

Objective

There is an interest in identifying a metabolic OA phenotype. We therefore assessed the relation of diabetes and cardiovascular disease to prevalent and incident radiographic (ROA) and symptomatic knee osteoarthritis (SxOA).

Design

In two large cohort studies of individuals with or at risk for knee OA, the Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), participants self-reported diabetes and cardiovascular disease (CVD) at baseline. We assessed the relation of baseline diabetes and CVD (exposures) to ROA and SxOA cross-sectionally and after 60 (MOST) or 48 (OAI) months of follow-up using logistic regression with GEE to account for 2 knees within an individual, adjusting for potential confounders.

Results

In MOST, 6,020 knees of

SUBMITTER: Kuusalo L 

PROVIDER: S-EPMC8020447 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature