Remodels the Immunosuppressive Tumor Microenvironment by Combination of Bacillus Calmette-Guerin and Anti-PD-L1 in an Orthotopic Triple-Negative Breast Cancer Mouse Model.

ABSTRACT:

Background

Targeting immunosuppressive tumor microenvironment (TME) is one of the important therapeutic strategies for triple-negative breast cancer (TNBC). The application of Bacillus Calmette-Guérin (BCG) in the clinical treatment of bladder cancer has shown that BCG is a strong inducer of immune activation and can remodel the immunosuppressive state of the TME. Meanwhile, previous studies have demonstrated that the 4T1 TNBC mouse model does not respond to anti-PD-L1 treatment alone. Therefore, it is necessary to explore the effect of BCG on TNBC, as well as the potential efficacy of BCG combined with anti-PD-L1.

Materials and methods

In this study, we studied the effects of BCG treatment on the lymphocytes and transcriptome in the TME of an orthotopic TNBC mouse model, an

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8020454 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature