Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions.

ABSTRACT: Lecithin:retinol acyltransferase and retinol-binding protein enable vitamin A (VA) storage and transport, respectively, maintaining tissue homeostasis of retinoids (VA derivatives). The precarious VA status of the lecithin:retinol acyltransferase-deficient (Lrat^-/-) retinol-binding protein-deficient (Rbp^-/-) mice rapidly deteriorates upon dietary VA restriction, leading to signs of severe vitamin A deficiency (VAD). As retinoids impact gut morphology and functions, VAD is often linked to intestinal pathological conditions and microbial dysbiosis. Thus, we investigated the contribution of VA storage and transport to intestinal retinoid homeostasis and functionalities. We showed the occurrence of intestinal VAD in Lrat^-/-Rbp^-/- mice, demonstrating

SUBMITTER: Honarbakhsh M 

PROVIDER: S-EPMC8020483 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature