In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019.

ABSTRACT:

Ethnopharmacological relevance

With the spread of Coronavirus Disease (2019) (COVID-19), combination with traditional Chinese medicine (TCM) has been widely used as a prevention and therapy strategy in China. Xin guan No.1 (XG-1) prescription is a preventive formula recommended by the Hunan Provincial Administration of TCM to prevent the pandemic of COVID-19.

Aim of the study

To explore the potential preventive mechanisms of XG-1 against COVID-19 in the combination of network pharmacology approach, single-cell RNA expression profiling analysis, molecular docking and retrospective study.

Materials and methods

Encyclopedia of Traditional Chinese Medicine (ETCM) database was used to determine the meridian tropism, active components and target genes of XG-1. Gene ontology

SUBMITTER: Wu H 

PROVIDER: S-EPMC8020622 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature