Shear stress induced by fluid flow produces improvements in tissue-engineered cartilage.

ABSTRACT: Tissue engineering aims to create implantable biomaterials for the repair and regeneration of damaged tissues. In vitro tissue engineering is generally based on static culture, which limits access to nutrients and lacks mechanical signaling. Using shear stress is controversial because in some cases it can lead to cell death while in others it promotes tissue regeneration. To understand how shear stress works and how it may be used to improve neotissue function, a series of studies were performed. First, a tunable device was designed to determine optimal levels of shear stress for neotissue formation. Then, computational fluid dynamics modeling showed the device applies fluid-induced shear (FIS) stress spanning three orders of magnitude on tissue-engineered cartilage (neocartilage). A benef

SUBMITTER: Salinas EY 

PROVIDER: S-EPMC8020626 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature