Relation between arousability and outcome of upper airway stimulation in the Stimulation for Apnea Reduction (STAR) Trial.

ABSTRACT:

Study objectives

Upper airway stimulation (UAS) is an innovative surgical treatment for obstructive sleep apnea; however, the treatment failure rate is approximately 22%. Easy arousability may limit the tolerability of stimulation and, by extension, its effectiveness. The odds ratio product (ORP) is a continuous electroencephalographic metric of arousal propensity (range: 0 [deep sleep] to 2.5 [full wakefulness]), and its rate of decline after arousal (ORP-9) is a risk factor for susceptibility to arousal in the presence of frequent arousal stimuli. We hypothesized that individuals with deeper sleep (low average ORP and low ORP-9) are more likely to respond to UAS.

Methods

ORP and ORP-9 were calculated from 126 baseline polysomnograms of participants in the STAR Trial. These

SUBMITTER: Yu JL 

PROVIDER: S-EPMC8020691 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature