Quantity - but not diversity - of secreted peptides and proteins increases with age in the tree frog Pithecopus nordestinus.

ABSTRACT:

Background

Amphibians inhabit the terrestrial environment, a conquest achieved after several evolutionary steps, which were still insufficient to make them completely independent of the aquatic environment. These processes gave rise to many morphological and physiological changes, making their skin (and cutaneous secretion) rich in bioactive molecules. Among the tree frogs, the secretion is composed mainly of peptides; but alkaloids, proteins and steroids can also be found depending on the species. The most known class of biologically active molecules is the antimicrobial peptides (AMPs) that act against bacteria, fungi and protozoans. Although these molecules are well-studied among the hylids, AMPs ontogeny remains unknown. Therefore, we performed peptidomic and proteomic analyses

SUBMITTER: Mariano DO 

PROVIDER: S-EPMC8020714 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature