Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice.

ABSTRACT: Inhalation of crystalline silica (cSiO₂) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO₂ unleashes a vicious cycle of inflammation and cell death in the lung that triggers interferon-regulated gene expression, ectopic lymphoid structure (ELS) development, elevation of local and systemic autoantibodies (AAbs), and glomerulonephritis. However, cSiO₂-induced inflammation and onset of autoimmunity can be prevented by inclusion of the ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) into the diet of these mice. Since cSiO₂ both causes cell death and interferes with efferocytosis, secondary necrosis of residual cell corpses might provide a rich and varied aut

SUBMITTER: Rajasinghe LD 

PROVIDER: S-EPMC8020726 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature